Search results for "Major conclusion"
showing 2 items of 2 documents
Pharmacokinetics in Drug Discovery
2007
The aim of this current review is to summarize the present status of pharmacokinetics in Drug Discovery. The review is structured into four sections. The first section is a general overview of what we understand by pharmacokinetics and the different LADMET aspects: Liberation, Absorption, Distribution, Metabolism, Excretion, and Toxicity. The second section highlights the different computational or in silico approaches to estimate/predict one or several aspects of the pharmacokinetic profile of a discovery lead compound. The third section discusses the most commonly used in vitro methodologies. The fourth and last section examines the various approaches employed towards the pharmacokinetic …
Towards an Understanding of the Causes of Difficulties in Debugging
2018
Debugging remains one of the areas that have seen little progress since the early days of programming. We argue that the academic approach of observational studies is incapable of capturing the essence of debugging in complex software. Instead, reflections by programmers may provide a better description of the debugging nature and challenges. In this article, we describe a study where we capture the reflections of programmers on thorny bugs that exemplify the major sources of difficulties in debugging. More importantly, we provide suggestions on what could have been done to avoid such thorny bugs from occurring with the same level of difficulties. As a major conclusion, we argue that the be…